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Who owns knowledge and how do we know what is known?

One of my sayings is “Where there is a debate, there is research” – but there are problems in the research.

    To discuss this point I must first explain how science works. In universities, where much of all published research is done, research is broken up into small teams. Each team is led by a primary investigator. Their main job is to plan the research and get funding for it. They write up an application for research money, often to a public source, but sometimes a private source. For this, the application must sound fantastic: never heard of, could cure something, could find out something amazing etc. etc. Once they get the funding, they will hire staff on short term contracts and rope in students such as Ph.D. students to do the research. The primary investigator must then report back to the research funder on how things are going. Once they have results, they will write up the research in a journal article and submit it to one of the many journals out there – you may have heard of Science or Nature.

     After you submit the article, the editor of the journal will send your article to other scientists in the field to ensure the research is good; the article will then be returned to authors with the corrections and, whether it was perfect research or not, there will be corrections.  Once corrected, the process is repeated and then it is published with the authors’ names on it (the person who did the most work coming first and the primary investigator last). Now this is important. For the careers of all people in science, there is a saying: “PUBLISH OR PERISH.” This means get as many journal articles as possible with you as the first author or your career will perish.

      The first problem with this is availability. I regularly cringe at what the media and the public say with the illusion of having knowledge. They’ll spin some message with jargon, statistics and – worst of all – personal anecdotes, to sound scientific; sound like they know something; sound like they read the research. I think these morons are spreading ignorant propaganda. But, on second thought, it’s not their fault. To publish something without doing any research takes three minutes. To do the research and then get it published in a journal can take years.

      Then, after all that effort to get published in a journal, who reads it? Not the public – because most journal articles cost money to read. It would cost the average internet user $60USD to read one paper, and to do a basic review of the current literature on a topic would require reading upwards of 100 papers. So what do they read instead? “Yahoo! Answers” or something like that. This means that information today is owned by the journals and ignorance is free. Soooo, what gets more hits? What is read more? What is BELIEVED more? IGNORANCE!

      Another problem is positive publishing bias. This is basically the fact that things that work get published in journals and things that fail get rejected.  Here is an example: imagine that I come up with the idea that humming loudly cures cancer, and I do a very thorough experiment to test this idea. If I was wrong, there is no way in the world any scientific journal would publish this research – and they would think I was a moron for thinking this. However, if I was right, I would be published in possibly a very good journal. This is an extreme example, but it does occur all the time. Now you wouldn’t think that would be a problem if the research is good and the result is positive. That means you’ve cured something and the world should know – if it doesn’t work, who cares? Why does the world need to know that something doesn’t work? This comes down to statistics.

      If you have two groups that vary, but their averages are different, how do you know whether this difference is real or just because of the variation in the population compared to the sample size? For example, if two people had two coins and then flipped them at the same time, and one landed on heads and the other tails, does this mean the coins are different? No – because this could have occurred by chance. If they flipped them five times each and one always landed on heads and the other always landed on tails, this also could have occurred by chance. However, you can calculate how confident you are that this didn’t occur by chance (for one coin it would be 0.5 X 0.5 X 0.5 X 0.5 X 0.5 = 0.0031, or a 3 in 1000 chance). Once you’ve flipped them 100 times each and one is still only heads and one is still only tails, it seems clear that the coins are different. In science a 1 in 20 (0.05) chance that something occurred by chance is seen as a “significant” difference – as real and not by chance.

      Now back to the positive publishing bias. What if twenty groups in the world are working on seeing if the same drug can cure cancer (that is entirely realistic), and 19 of them find that a drug has no positive effect on a disease? These may get rejected from journals and we would never know about their research. But if 1 of those groups, purely by chance, found that the drug seemed to have a significant effect on cancer, they would be more likely to get published. Then, when the average researcher went and read up on the drug, they would only find the one article on it – saying that the drug worked – and they would never know about the 19 other groups that found it did not. This drug that actually had no effect on the disease would now, according to the literature, be seen as a future remedy for cancer.

       Now, when you add the PUBLISH OR PERISH pressure to the situation, this positive publication bias situation gets worse. They must get published and to get published it has got to be positive. Now scientists aren’t coming from an unbiased thirst-for-knowledge situation; they are coming from an “I hope this works” point of view. This isn’t good for research, and it isn’t good for knowledge.

 OK, again, not the complete story – just some things to think about. Comment below; I would love to discuss further.

Hashing out the Marijuana debate.

This could be a biggie. So there are lots of questions and lots of stances on this issue, legalize, medicinal, decriminalize. I’m going to comment on a bit and wait for comments from the public and then I’ll expand on those issues.

A lot for good arguments are already out there, both for and against legalization marijuana. So I’m going to start with one you may not have thought of…..

What happens when we compare Prozac the antidepressant to marijuana?

     Prozac has a better safety profile, it has medicinal uses as well, less side-effects, it can also help people be happy, it acutely has no effects on driving skills or work ethic unlike marijuana, it doesn’t increase food intake, in general it is an OK drug. So….. should it be sold at cosmic corner without prescription? Should people have the CHOICE to do Prozac? Just at your local dairy. People should wear shirts featuring the little green and white Prozac pill, and listen to artists sing about it. What about advertising and two bottles of Prozac for one deals etc. To most people this idea seems ridiculous, but why? In every way it is a milder drug than Marijuana, so why not? In fact why not open it up a little more, stronger antidepressants like MAOI’s or perhaps a brain numb-er like lithium (it has been proven that cities with more lithium in their water have less suicides!).

    Now there are two main openings here for the pro-marijuana movement. One is that marijuana is natural and there some how different and better than prozac, and the other is that people should be able to choose what drugs they do and prozac should be sold at the local dairy. Let me address each one.

      The natural mechanism of cannabinoids actually lies within the brain. Your body produces marijuana like substances called endocannabinoids (or more correctly the marijuana plant produces substances like endocannabinoids). These endocannabinoids are produced in tiny tiny amounts and bind to receptors in the brain. Among other reasons, they are produced after a stressful event to reduce neuronal firing. I love that, think about the evolutionary background of that. You’re running away from a lion and this produces all sorts of stress hormones. You then out run the lion and need to relax, but stay alert (paranoia), you need food (increased appetite), you need to conserve your resources (suppressed immune system), but you need to keep your heart rate up in case of further activity needed (lion reappears). This is the normal function of your endocannabinoids, this is the natural way your cannabinoids are supposed to work, just because something is produced in nature does not mean we should consume it to high-jack our biological system to make us feel things and it doesn’t mean that it is natural to consume. The box jelly fish is in nature that doesn’t mean I should consume it. Or more appropriately- opium is a natural drug that gets you high and has huge medicinal benefit, does that mean we should legalize this? Should we be able to choose Opium?

      Those who would argue that we should allow Prozac in the dairy. They are treading a scary line. To me this really asks the question…. what is choice? Your normal system of choice involves having a plan- deciding whether to do it- evaluating whether it was a good idea and this feeds back on the previous step to help you choose in the future. This process occurs in the brain, and each step communicates with each other through signalling molecules. Drugs target these signalling molecules and give their own signal thus skewing the very mechanism of choice. Now I know that is a weird thought, but think about it, it happens every day. Does coffee taste that good? Coffee and tea are the top two selling drinks in the world. Do they taste THAT good? what’s the third most sold drink? Coke. Is lemonade that much worse than coke. We ALL drink coffee and we ALL drink coke, but we don’t ALL listen to the same music? We don’t all like the same meals? we don’t like the same art? what is it about those three drinks that makes them so popular? Caffeine. How has caffeine done this? well it affects the very processes of choice, and it is the weaker kind of drug that effects choice, yet it has conquered the world. So legalizing drugs that in their nature affect our decision making machine (the brain), isn’t that taking away choice? rather than preserving it?

This is just the discussion starter, it is no way a complete argument- so let me know what you think.

Are scientists open minded?

     It is commonly believed that scientists (and science as a whole) aren’t open minded, by this it is meant that they aren’t open to new ideas. I think this is the opposite of the truth. If you look at it, medicine 150 years ago was very different to medicine today. Have you heard of bloodletting? That is where a “doctor” cuts a vein, normally on your arm, to release blood. This cures many things apparently, particularly fever. Believe it or not this weird practice was wide spread! All over the western world doctors were taking blood for the “good” of the people. In fact it was killing people, by the 1000’s. Even good old George Washington most probably died not from the throat infection but from the 3 litres of blood three doctors took from him over the course of a night. Then there was a movement, key to this movement was an experiment where two young doctors who didn’t perform bloodletting, challenge an older doctor to an experiment. The challenge was set, as a patient came in the patient was randomly assigned to one of the three doctors. Once each doctor had around 100 patients they looked at the death rate of each doctor. The older bloodletting doctor had lost 35, how many did the others lose? Between them…… 4! So what happened? More experiments (science) were done to confirm the result…. Then what happened? Science and medicine changed its mind, it was open to new ideas and now no one performs bloodletting (except in rare cases where it is actually good for you).

     Compare this to say… homeopathy which has had many many many experiments (so many I wonder why they’re still doing them) very similar to the one described above, where time and time again the patients that go to the homeopath are no better than those who receive no treatment, and are worse than those who receive scientifically proven medical treatments. Yet despite these experiments (science), has homeopathy gone away or changed it practices? Has homeopathy gone the same route as bloodletting? NO! Why because homeopaths are closed minded, they refuse to see that what they are doing doesn’t work. Medicine has changed vastly over the last 100 years, as knowledge has changed over the last 100 years. Yet homeopathy and others haven’t changed at all. So to the homeopaths and alike… open your mind man…