Category Archives for Blog

Repurposing existing drugs for Alzheimer’s disease.

There is growing evidence for the role inflammation in Alzheimer’s disease progression. Genome wide association studies (GWAS) have found that variants of genes involved in regulating innate immune function confer a greater risk in developing Alzheimer’s disease(1 & 2). Examples … Continue reading

11. August 2016 by jackrrivers
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How does your body know when its damaged? New research on stroke and inflammation.

My lab in Manchester has just released a fascinating research paper that touches on the lovely scientific elements of serendipity, hypothesis falsification and surprise results. This paper has continued the great scientific tradition of generating more questions than answers. Have … Continue reading

10. April 2015 by jackrrivers
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Humans have at least one genetic disease – In the future could we have hundreds?

What is the point of having a blog if you are not going to engage in off-the-cuff speculation. So here goes- Every one of our genes is under constant threat of mutation from radiation, free radicals and merely being mis-copied … Continue reading

03. February 2015 by jackrrivers
Categories: Blog | 3 comments

The Unsaid Criticisms of Science

Two things that science is struggling with at the moment are reproducibility and translatability. The problem where results are reported by a lab and then other labs struggle to reproduce the same result is happening more and more. Begley et al. … Continue reading

11. July 2014 by jackrrivers
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Darwin vs Lamarck or Darwin and Lamarck?

I was reading about Jean-Baptiste Lamarck and it dawned on me that perhaps he was partly right about evolution. So, most people believe that Darwin was the first to propose the theory of evolution, but really, evolution just states that … Continue reading

01. July 2014 by jackrrivers
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Simple Statistics Provide Poor Prognosis for Science!

An article was published in 2006 called Why most published research findings are false(1). I have skim read it a few times, but recently I put the time in to read it thoroughly. It basically goes through a simple statistical analysis … Continue reading

20. June 2014 by jackrrivers
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Causation and Anti-Cancer Miracle Foods

Here is an interesting study that suggests your average diet contains both anti-cancer and cancer causing compounds and the effect sizes cancel out. For example bacon increases your risk of cancer and onion decreases your risk. So eat bacon and onions … Continue reading

30. May 2014 by jackrrivers
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Why is Animal Research Failing?

Introduction Anyone who watches the news frequently might be aware of a very wide and deep fissure that exists in science today. They will be aware of this fissure because every week it appears that a disease is cured by … Continue reading

26. May 2014 by jackrrivers
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Who owns knowledge and how do we know what is known?

One of my sayings is “Where there is a debate, there is research” – but there are problems in the research.     To discuss this point I must first explain how science works. In universities, where much of all published … Continue reading

20. December 2011 by jackrrivers
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Hashing out the Marijuana debate.

This could be a biggie. So there are lots of questions and lots of stances on this issue, legalize, medicinal, decriminalize. I’m going to comment on a bit and wait for comments from the public and then I’ll expand on … Continue reading

08. December 2011 by jackrrivers
Categories: Blog | 10 comments

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